Norditropin SimpleXx View full size

Norditropin SimpleXx

5mg (15iu) and 10mg (30iu) cartridges

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Norditropin SimpleXx
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Norditropin SimpleXx 5mg/1.5ml (15IU) and 10mg (30IU)


Norditropin SimpleXx 5mg/1.5ml (15IU) and 10mg (30IU) solution for injection cartridges are indicated in children with growth problems, Turner’s syndrome, in people with certain kidney problems and in children who are too small for their age.

Norditropin is supplied by Novo Nordisk Limited and contains:

  • histidine
  • hydrochloric acid for pH adjustment
  • mannitol
  • phenol
  • poloxamer 188
  • sodium hydroxide for pH adjustment
  • somatropin
  • water for injections

Norditropin Simplexx is manufactured using recombinant DNA technology in E. coli secretion expression system.


Caution must be taken if the patient:

  • is a child who has stopped growing completely
  • is over 60 years old
  • is allergic or sensitive to any ingredients
  • is suffering from complications caused by surgery, trauma, or other medical conditions
  • has a respiratory infection, tumour, or kidney problems
  • has diabetes or is at risk for developing diabetes e.g. family history of diabetes, has certain skin problems or is obese
  • has or have had brain or central nervous system problems
  • has pituitary problems
  • has Prader-Willi syndrome
  • has Silver-Russell syndrome
  • has sleep apnoea

Norditropin SimpleXx is contraindicated in children under the age of four and in those who are having a kidney transplant.

Drug interaction

The following drugs may interact with Norditropin SimpleXx:

  • ciclosporin
  • gonadotrophin
  • insulin

The following types of drugs may also interact with Norditropin SimpleXx:

  • anabolic steroids
  • anticonvulsants
  • corticosteroids
  • glucocorticosteroids
  • hormones
  • medicines that are metabolised by the cytochrome P450 system
  • oestrogens
  • sex steroids
  • thyroid hormones

Doctor must be informed if the patients is taking any of the above, or is undergoing treatment with any alternative medicaments, including vitamins, herbal supplements, and non-prescription drugs.


For the best result from Norditropin SimpleXx it should be taken in the evening.

Do not use Norditropin SimpleXx if the packaging has been tampered with, or if it shows any signs of damage. If you started a cartridge, leave it in the pen. Once opened, store it in a fridge at 2-8°C, and dispose no later than 28 days after opening. You can also store it at the room temperature; however, you must dispose of it 21 days after opening. Store it in the carton box (it is light sensitive), out of the sight and reach of children and pets. Do not freeze, or use after the expiry date shown on the packaging.


In children, side-effects are usually uncommon or rare.

In adults, oedema of the extremities is very common (1 in 10). Less common side effects include headaches, joint pain or stiffness, muscle pain or tenderness and paraesthesia. In addition, carpal tunnel syndrome, diabetes, pain at the injection sites, itching or muscle stiffness is uncommon. On rare occasions skin rash may occur, sometimes in children.

Other symptoms (with unknown frequencies) include:

  • abnormal laboratory test results
  • bone problems
  • ear problems especially in people with Turner's syndrome
  • hypersensitivity reactions
  • increase in the size of hands and feet
  • increased blood glucose
  • intracranial hypertension
  • leukaemia
  • metabolic problems
  • production of anti-Norditropin SimpleXx antibodies
  • reduced glucose tolerance 
  • thyroid problems


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