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Humatrope pen

6mg (18iu) and 12mg (36iu) pen devices

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Humatrope pen
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Humatrope is a human growth hormone (HGH) product produced using E. coli recombinant technology by Eli Lilly. Humatrope HGH is identical to naturally occurring HGH and comes in 3 different strengths: 6mg (18IU), 12mg (36IU), and 24mg (72IU) liquid (3ml) cartridges. Humatrope should be used with Humatro Pen.

Humatrope (Somatropin, rDNA origin, for injection) is a polypeptide hormone of recombinant DNA origin, synthesized in a modified Escherichia coli strain where the gene for human GH has been inserted into the bacterial genome. The peptide consists of 191 amino acid residues with a molecular weight of about 22kD. The amino acid sequence of this peptide is identical to that of human GH of pituitary origin.

Humatrope is manufactured in a form of a sterile lyophilized powder intended for subcutaneous or intramuscular administration after reconstitution with the accompanying diluent. Humatrope is a highly purified preparation; however, Phosphoric acid and/or NaOH may be added to adjust the pH. Once reconstituted, solution has a pH of approximately 7.5. This product is oxygen sensitive.

Vials: Each vial of Humatrope contains 5mg Somatropin (15 IU); 25mg mannitol; 5mg glycine; and 1.13mg dibasic sodium phosphate and is supplied with an accompanying 5mL vial of diluting solution containing Water for Injection with 0.3% metacresol as a preservative, and 1.7% glycerin.

Cartridge: Cartridges of Humatrope come at 6mg, 12mg or 24mg of Somatropin. Each cartridge is supplied with an accompanying syringe containing approximately 3mL of diluent: Water for Injection; 0.3% metacresol as a preservative; and 1.7%, 0.29%, or 0.29% glycerin.

Side effects

Male patients with Prader-Willi syndrome are more susceptible to developing breathing problems when using Somatropin; especially severely overweight children, those with pre-existing lung/breathing problems (like sleep apnea, lung infections, lung disease). Children should be continuously monitored for upper airway obstruction prior and during the treatment; doctor should be informed immediately if any signs for upper airway obstruction appear: shortness of breath, coughing, or new or increased snoring.

Some of the less serious side effects are as follow:

  • headache
  • tiredness
  • redness, soreness, swelling, rash, itching, pain, or bruising at the injection sites
  • arms or legs pain
  • joint stiffness or pain
  • muscle pain
  • cold symptoms like stuffy nose, sneezing, or sore throat


Contact your doctor immediately if you notice any of the following adverse side effects:   

  • increased heart rate
  • severe pain in the upper stomach spreading to the back,
  • nausea and vomiting
  • increased thirst,
  • increased urination,
  • hunger, dry mouth,
  • fruity breath odour,
  • drowsiness, dry skin,
  • blurred vision, and weight loss
  • sudden and severe pain behind the eyes
  • vision changes
  • swelling in the head, face, hands, or feet
  • numbness or tingling in wrists, hands, or fingers
  • unusual or unexplained weight gain
  • persistent cold intolerance
  • development of a limp
  • ear pain or hearing problems
  • change in the appearance or size of any mole


Serious allergic reactions are very unlikely using Humatrope. Nevertheless, get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.


Inform your doctor if you are allergic to Somatropin and of any other allergies as it may contain some inactive ingredients that are potential allergens (benzyl alcohol, glycerin). Doctor should be aware of patient’s medical history prior administrating Humatrope, especially of any adrenal gland problems, diabetes or family history of diabetes, obesity, kidney disease, cancer, thyroid problems, scoliosis, or Turner syndrome.

Humatrope is contraindicated in patients with: eye problems (diabetic retinopathy), major surgery or trauma, severe breathing problems (acute respiratory failure), undergoing therapy for tumours (cancer), Prader-Willi syndrome or if their normal growth has stopped (closed epiphyses).

During administration in new-borns, Humatrope must be mixed with sterile water for injection without preservatives (benzyl alcohol); use of BA is especially risky in under-weight infants and is more dangerous with high amounts of BA. Symptoms include sudden gasping, low blood pressure, or a very slow heartbeat. Some children may be also more sensitive to some side effects, especially to pancreatitis.

Elderly patients may be more sensitive to effects thus must be administered with caution.

Use during pregnancy only if necessary. It is unclear if Humatrope can be passed into breast milk; therefore, consult your doctor before breast-feeding.

Drug interactions

Some drugs may interact with Humatrope, such as drugs to treat diabetes (insulin, sulfonylureas such as glyburide), oestrogen hormone replacement, or glucocorticoids (prednisone, hydrocortisone).


Symptoms of overdose include: severe headache, nausea, or vomiting; sudden onset of sweating, fatigue, shakiness, confusion (hypoglycaemia), persistent swelling of hands and feet. If you suddenly experience any of such, seek emergency medical help immediately.


Do not share Humatrope with others. Keep away from children and pets.


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